The Dance Between Schwann Cells and Macrophages During the Repair of Peripheral Nerve Injury.
10.1007/s12264-025-01427-y
- Author:
Wei LI
1
;
Guixian LIU
1
;
Jie LIANG
1
;
Xiao WANG
1
;
Meiying SONG
1
;
Xiaoli LIU
1
;
Luoyang WANG
1
;
Zijie YANG
2
;
Bei ZHANG
3
Author Information
1. Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
2. Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
3. Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, 266071, China. zhangbei124@aliyun.com.
- Publication Type:Review
- Keywords:
Interaction;
Macrophages;
Peripheral nerve injury;
Regeneration;
Schwann cells
- MeSH:
Schwann Cells/metabolism*;
Peripheral Nerve Injuries/physiopathology*;
Animals;
Macrophages/immunology*;
Nerve Regeneration/physiology*;
Humans;
Cell Movement/physiology*
- From:
Neuroscience Bulletin
2025;41(8):1448-1462
- CountryChina
- Language:English
-
Abstract:
Schwann cells and macrophages are the main immune cells involved in peripheral nerve injury. After injury, Schwann cells produce an inflammatory response and secrete various chemokines, inflammatory factors, and some other cytokines to promote the recruitment and M2 polarization of blood-derived macrophages, enhancing their phagocytotic ability, and thus play an important role in promoting nerve regeneration. Macrophages have also been found to promote vascular regeneration after injury, promote the migration and proliferation of Schwann cells along blood vessels, and facilitate myelination and axon regeneration. Therefore, there is a close interaction between Schwann cells and macrophages during peripheral nerve regeneration, but this has not been systematically summarized. In this review, the mechanisms of action of Schwann cells and macrophages in each other's migration and phenotypic transformation are reviewed from the perspective of each other, to provide directions for research on accelerating nerve injury repair.
