Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation.
10.1007/s12264-025-01404-5
- Author:
Wen-Guang LI
1
;
Lan-Xin LI
1
;
Rong-Xin SONG
2
;
Xu-Peng WANG
3
;
Shi-Yan JIA
1
;
Xiao-Yi MA
1
;
Jing-Yu ZHANG
4
;
Gang-Feng YIN
5
;
Xiao-Ming LI
6
;
Li-Min ZHANG
7
,
8
Author Information
1. Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Cangzhou, 061000, China.
2. Department of Anesthesiology, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No. 2 Hospital), Cangzhou, 061000, China.
3. The Third Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
4. Clinical Lab, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No. 2 Hospital), Cangzhou, 050200, China.
5. Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, 061000, China.
6. Hebei Key Laboratory of Integrated Traditional and Western Medicine in Osteoarthrosis Research, Cangzhou, 061000, China.
7. Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Cangzhou, 061000, China. azai2010@
8. com.
- Publication Type:Journal Article
- Keywords:
Astrocytes;
Ca2+ signal;
Cognition;
Cross-frequency coupling;
HSR
- MeSH:
Animals;
Astrocytes/metabolism*;
Shock, Hemorrhagic/metabolism*;
Resuscitation/adverse effects*;
Male;
Mice;
Calcium Signaling/physiology*;
Mice, Inbred C57BL;
Septal Nuclei/metabolism*;
Cognitive Dysfunction/etiology*;
Disease Models, Animal;
Cognition Disorders/etiology*
- From:
Neuroscience Bulletin
2025;41(8):1403-1417
- CountryChina
- Language:English
-
Abstract:
Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation. Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons. Although hemorrhagic shock and resuscitation (HSR) injury can impair cognition, it remains unclear how this insult directly affects astrocytes. In this study, we established an HSR model by bleeding and re-transfusion in mice. The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes, and the results suggest that mice experience cognitive impairment following exposure to HSR. In the HSR group, the power spectral density of β and γ oscillations decreased, and the coupling of the θ oscillation phase and γ oscillation amplitude was abnormal, which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure. In brief, cognitive impairment in mice is strongly correlated with Ca2+ signal strength in lateral septum astrocytes following HSR.
