Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis.
10.1007/s12264-025-01370-y
- Author:
Shasha ZHANG
1
;
Hairong XIAO
2
;
Yanqin LIN
2
;
Xujun TANG
2
;
Wei TONG
2
;
Buwei SHAO
3
;
He LI
4
;
Lei XU
5
,
6
;
Xiaoqiong DING
7
;
Renjie CHAI
8
Author Information
1. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. zhangshasha@seu.edu.cn.
2. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
3. School of Medicine, Faculty of Medical & Health Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.
4. Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. lihe@wzhospital.cn.
5. Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250022, China. sdphxl@
6. com.
7. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. ding_xq81@hotmail.com.
8. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.
- Publication Type:Review
- Keywords:
Ferroptosis;
Necroptosis;
Programmed cell death;
Pyroptosis;
Sensorineural hearing loss
- MeSH:
Humans;
Hearing Loss, Sensorineural/metabolism*;
Necroptosis/drug effects*;
Pyroptosis/drug effects*;
Ferroptosis/drug effects*;
Animals
- From:
Neuroscience Bulletin
2025;41(6):1085-1102
- CountryChina
- Language:English
-
Abstract:
Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.
