What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer's Disease?
10.1007/s12264-025-01399-z
- Author:
Jinyue ZHOU
1
;
Xiaoli SUN
2
;
Keren WANG
3
;
Min SHEN
4
;
Jingbo YU
1
;
Qi YAO
1
;
Hang HONG
5
,
6
;
Chunlan TANG
6
,
7
;
Qinwen WANG
8
Author Information
1. Health Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China.
2. Department of Chemistry, Lishui University, Lishui, 32300, China.
3. Health Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China.
4. Reference Laboratory, Medical System Biotechnology Co., Ltd, Ningbo, 315104, China.
5. Health Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China. honghang28@
6. com.
7. Health Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China. chunlant@
8. Health Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China. wangqinwen@nbu.edu.cn.
- Publication Type:Review
- Keywords:
Alzheimer’s disease;
Central nervous system;
Non-neurological diseases;
Peripheral system
- MeSH:
Alzheimer Disease/therapy*;
Humans;
Brain/pathology*
- From:
Neuroscience Bulletin
2025;41(7):1289-1301
- CountryChina
- Language:English
-
Abstract:
Alzheimer's disease (AD) is regarded as a neurodegenerative disease, and it has been proposed that AD may be a systemic disease. Studies have reported associations between non-neurological diseases and AD. The correlations between AD pathology and systemic (non-neurological) pathological changes are intricate, and the mechanisms underlying these correlations and their causality are unclear. In this article, we review the association between AD and disorders of other systems. In addition, we summarize the possible mechanisms associated with AD and disorders of other systems, mainly from the perspective of AD pathology. Regarding the relationship between AD and systemic pathological changes, we aim to provide a new outlook on the early warning signs and treatment of AD, such as establishing a diagnostic and screening system based on more accessible peripheral samples.
