Evolution of the Rich Club Properties in Mouse, Macaque, and Human Brain Networks: A Study of Functional Integration, Segregation, and Balance.
10.1007/s12264-025-01393-5
- Author:
Xiaoru ZHANG
1
;
Ming SONG
2
;
Wentao JIANG
1
;
Yuheng LU
3
;
Congying CHU
1
;
Wen LI
1
;
Haiyan WANG
1
;
Weiyang SHI
1
;
Yueheng LAN
4
;
Tianzi JIANG
1
Author Information
1. Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
2. Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. msong@nlpr.ia.ac.cn.
3. School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
4. School of Science, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
- Publication Type:Journal Article
- Keywords:
Brain evolution;
Cross species;
Functional integration;
Functional segregation;
Rich-club
- MeSH:
Animals;
Humans;
Brain/diagnostic imaging*;
Mice;
Male;
Nerve Net/diagnostic imaging*;
Macaca;
Female;
Neural Pathways/diagnostic imaging*;
Magnetic Resonance Imaging;
Biological Evolution;
Adult;
Diffusion Magnetic Resonance Imaging;
Brain Mapping;
Species Specificity;
Mice, Inbred C57BL
- From:
Neuroscience Bulletin
2025;41(9):1630-1644
- CountryChina
- Language:English
-
Abstract:
The rich club, as a community of highly interconnected nodes, serves as the topological center of the network. However, the similarities and differences in how the rich club supports functional integration and segregation in the brain across different species remain unknown. In this study, we first detected and validated the rich club in the structural networks of mouse, monkey, and human brains using neuronal tracing or diffusion magnetic resonance imaging data. Further, we assessed the role of rich clubs in functional integration, segregation, and balance using quantitative metrics. Our results indicate that the presence of a rich club facilitates whole-brain functional integration in all three species, with the functional networks of higher species exhibiting greater integration. These findings are expected to help to understand the relationship between brain structure and function from the perspective of brain evolution.
