Transcranial temporal interference stimulation precisely targets deep brain regions to regulate eye movements.
10.1007/s12264-025-01387-3
- Author:
Mo WANG
1
;
Sixian SONG
2
;
Dan LI
1
;
Guangchao ZHAO
3
;
Yu LUO
4
;
Yi TIAN
2
;
Jiajia ZHANG
2
;
Quanying LIU
5
;
Pengfei WEI
6
Author Information
1. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
2. Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
3. Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
4. Shenzhen Zhongkehuayi Technology Co., Ltd, Shenzhen, 518107, China.
5. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. liuqy@sustech.edu.cn.
6. Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. pf.wei@siat.ac.cn.
- Publication Type:Journal Article
- Keywords:
Eye movement;
Finite element method;
Superior colliculus;
Temporal interference stimulation;
Tissue phantom;
Transcranial electrical stimulation
- MeSH:
Animals;
Superior Colliculi/physiology*;
Transcranial Direct Current Stimulation/methods*;
Eye Movements/physiology*;
Male;
Mice;
Mice, Inbred C57BL
- From:
Neuroscience Bulletin
2025;41(8):1390-1402
- CountryChina
- Language:English
-
Abstract:
Transcranial temporal interference stimulation (tTIS) is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures. This study explores the neural and behavioral effects of tTIS on the superior colliculus (SC), a region involved in eye movement control, in mice. Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation. In vivo experiments, including Ca2+ signal recordings and eye movement tracking, showed that tTIS effectively modulates SC neural activity and induces eye movements. A significant correlation was found between stimulation frequency and saccade frequency, suggesting direct tTIS-induced modulation of SC activity. These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements, highlighting its potential for neuroscientific research and therapeutic applications.
