Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.
10.1007/s12264-025-01380-w
- Author:
Yin YUE
1
;
Youming TAN
2
;
Pin YANG
3
;
Shu ZHANG
3
;
Hongzhen PAN
4
;
Yiran LANG
5
;
Zengqiang YUAN
6
Author Information
1. The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China. yuey17@tsinghua.org.cn.
2. Hengyang Medical School, University of South China, Hengyang, 421001, China.
3. School of Basic Medical Sciences, Anhui Medical University, Hefei, 230022, China.
4. School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.
5. School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China. yiran.lang@bit.edu.cn.
6. The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China. zqyuan@bmi.ac.cn.
- Publication Type:Journal Article
- Keywords:
5-CSRTT;
Attention;
EEG;
Functional network;
c-Fos
- MeSH:
Animals;
Attention/physiology*;
Mice;
Brain/physiology*;
Male;
Electroencephalography;
Reaction Time/physiology*;
Brain Mapping;
Mice, Inbred C57BL;
Choice Behavior/physiology*;
Proto-Oncogene Proteins c-fos/metabolism*
- From:
Neuroscience Bulletin
2025;41(5):741-758
- CountryChina
- Language:English
-
Abstract:
Attention is the cornerstone of effective functioning in a complex and information-rich world. While the neural activity of attention has been extensively studied in the cortex, the brain-wide neural activity patterns are largely unknown. In this study, we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining, utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns. Our findings reveal that a wide range of brain regions are activated, notably in the high-order cortex, thalamus, and brain stem regions involved in advanced cognition and arousal regulation, with the central lateral nucleus of the thalamus as a strong hub, suggesting the crucial role of the thalamus in attention control. These results provide valuable insights into the neural network mechanisms underlying attention, offering a foundation for formulating functional hypotheses and conducting circuit-level testing.
