Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.
10.1007/s12264-025-01373-9
- Author:
Jiejun ZHANG
1
;
Peilin HUANG
1
;
Lin LIN
1
;
Yingzhe CHENG
1
;
Weipin WENG
1
;
Jiahao ZHENG
1
;
Yixin SUN
1
;
Shaofan JIANG
2
;
Xiaodong PAN
3
,
4
Author Information
1. Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
2. Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China. 343594970@qq.com.
3. Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, China. pxd77316@
4. com.
- Publication Type:Journal Article
- Keywords:
Cognition;
Color discrimination;
NODDI;
Non-demented population;
White matter microstructure
- MeSH:
Humans;
White Matter/pathology*;
Male;
Female;
Cognitive Dysfunction/physiopathology*;
Middle Aged;
Aged;
Color Perception/physiology*;
Brain/pathology*;
Neuropsychological Tests;
Diffusion Tensor Imaging
- From:
Neuroscience Bulletin
2025;41(8):1364-1376
- CountryChina
- Language:English
-
Abstract:
Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging. However, investigations into the microstructural pathology of brain white matter (WM) associated with these deficits remain limited. This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination, utilizing Neurite Orientation Dispersion and Density Imaging (NODDI), and to explore their correlations with cognitive functions and cognition-related plasma biomarkers. The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls, characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index. Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation, superior longitudinal fasciculus, cingulum, and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers. These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction, potentially serving as early markers for cognitive decline.
