Embracing Internal States: A Review of Optimization of Repetitive Transcranial Magnetic Stimulation for Treating Depression.
10.1007/s12264-024-01347-3
- Author:
Tingting WU
1
;
Qiuxuan YU
1
;
Ximei ZHU
2
;
Yinjiao LI
2
;
Mingyue ZHANG
2
;
Jiahui DENG
3
;
Lin LU
4
Author Information
1. Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder, Chinese Academy of Medical Sciences (No. 2018RU006), Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
2. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100080, China.
3. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100080, China. jiahuideng2012@bjmu.edu.cn.
4. Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder, Chinese Academy of Medical Sciences (No. 2018RU006), Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. linlu@bjmu.edu.cn.
- Publication Type:Review
- Keywords:
Circadian rhythm;
Depression;
Personalized medicine;
State dependency;
rTMS
- MeSH:
Humans;
Transcranial Magnetic Stimulation/methods*;
Depressive Disorder, Major/physiopathology*;
Neuronal Plasticity/physiology*;
Brain/physiopathology*
- From:
Neuroscience Bulletin
2025;41(5):866-880
- CountryChina
- Language:English
-
Abstract:
Repetitive transcranial magnetic stimulation (rTMS) is a rapid and effective therapy for major depressive disorder; however, there is significant variability in therapeutic outcomes both within and across individuals, with approximately 50% of patients showing no response to rTMS treatment. Many studies have personalized the stimulation parameters of rTMS (e.g., location and intensity of stimulation) according to the anatomical and functional structure of the brain. In addition to these parameters, the internal states of the individual, such as circadian rhythm, behavior/cognition, neural oscillation, and neuroplasticity, also contribute to the variation in rTMS effects. In this review, we summarize the current literature on the interaction between rTMS and internal states. We propose two possible methods, multimodal treatment, and adaptive closed-loop treatment, to integrate patients' internal states to achieve better rTMS treatment for depression.
