The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders.
10.1007/s12264-024-01343-7
- Author:
Xin LIU
1
;
Wei WANG
2
;
Qiucheng NIE
1
;
Xinjing LIU
1
;
Lili SUN
1
;
Qiang MA
2
;
Jie ZHANG
3
;
Yiju WEI
4
Author Information
1. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
2. Cancer Biology Institute, Baotou Medical College, Baotou, 014010, China.
3. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China. jiezhang@sdfmu.edu.cn.
4. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China. weiyiju@sdfmu.edu.cn.
- Publication Type:Review
- Keywords:
Ferroptosis;
Iron;
Neurological disorders;
Ubiquitin-proteasome system
- MeSH:
Ferroptosis/physiology*;
Humans;
Proteasome Endopeptidase Complex/metabolism*;
Nervous System Diseases/metabolism*;
Animals;
Ubiquitin/metabolism*;
Iron/metabolism*
- From:
Neuroscience Bulletin
2025;41(4):691-706
- CountryChina
- Language:English
-
Abstract:
Ferroptosis is a form of cell death elicited by an imbalance in intracellular iron concentrations, leading to enhanced lipid peroxidation. In neurological disorders, both oxidative stress and mitochondrial damage can contribute to ferroptosis, resulting in nerve cell dysfunction and death. The ubiquitin-proteasome system (UPS) refers to a cellular pathway in which specific proteins are tagged with ubiquitin for recognition and degradation by the proteasome. In neurological conditions, the UPS plays a significant role in regulating ferroptosis. In this review, we outline how the UPS regulates iron metabolism, ferroptosis, and their interplay in neurological diseases. In addition, we discuss the future application of small-molecule inhibitors and identify potential drug targets. Further investigation into the mechanisms of UPS-mediated ferroptosis will provide novel insights and strategies for therapeutic interventions and clinical applications in neurological diseases.
