Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function.
10.1007/s12264-024-01326-8
- Author:
Yue QIU
1
;
Song GAO
1
;
Xiaoqiong DING
2
;
Jie LU
3
;
Xinya JI
3
;
Wenli HAO
1
;
Siqi CHENG
1
;
Haolinag DU
1
;
Yajun GU
1
;
Chenjie YU
4
,
5
;
Cheng CHENG
5
,
6
;
Xia GAO
7
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
2. Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing, 210008, China.
3. Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
4. Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China. entphd@
5. com.
6. Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China. cheng_ds@
7. Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China. gaoxia@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Tnfaip6;
Hair cells;
Hearing loss;
Noise
- MeSH:
Animals;
Mice, Knockout;
Hair Cells, Auditory, Inner/pathology*;
Mice;
Mice, Transgenic;
Hearing Loss, Noise-Induced;
Evoked Potentials, Auditory, Brain Stem/physiology*
- From:
Neuroscience Bulletin
2025;41(3):421-433
- CountryChina
- Language:English
-
Abstract:
Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (TNFAIPs) are a family of translucent acidic proteins, and TNFAIP6 has a notable association with inflammatory responses. To date, there have been few reports on TNFAIP6 levels in the inner ear. To elucidate the precise mechanism, we generated transgenic mouse models with conditional knockout of Tnfaip6 (Tnfaip6 cKO). Evaluation of hair cell morphology and function revealed no significant differences in hair cell numbers or ribbon synapses between Tnfaip6 cKO and wild-type mice. Moreover, there were no notable variations in hair cell numbers or hearing function in noisy environments. Our results indicate that Tnfaip6 does not have a substantial impact on the auditory system.
