Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition.
10.1007/s12264-024-01327-7
- Author:
Bing-Ying WANG
1
;
Bo WANG
1
;
Bo CAO
1
;
Ling-Ling GU
1
;
Jiayu CHEN
1
;
Hua HE
2
;
Zheng ZHAO
3
;
Fujun CHEN
4
;
Zhiru WANG
5
Author Information
1. Institute and Key Laboratory of Brain Functional Genomics of Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
2. Department of Neurosurgery, Third Affiliated Hospital of Navy Military Medical University, Shanghai, 200438, China.
3. Institute and Key Laboratory of Brain Functional Genomics of Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China. zzhao@brain.ecnu.edu.cn.
4. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China. chenfujun@sjtu.edu.cn.
5. Institute and Key Laboratory of Brain Functional Genomics of Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China. zrwang@brain.ecnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Associative learning;
Hippocampus;
Long-term potentiation;
Schaffer collateral;
Synaptic plasticity;
Temporoammonic;
Trace conditioning
- MeSH:
Animals;
CA1 Region, Hippocampal/physiology*;
Male;
Association Learning/physiology*;
Neuronal Plasticity/physiology*;
Cues;
Memory/physiology*;
Synapses/physiology*;
Conditioning, Classical/physiology*;
Excitatory Postsynaptic Potentials/physiology*;
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors*;
Rats;
Optogenetics
- From:
Neuroscience Bulletin
2025;41(4):649-664
- CountryChina
- Language:English
-
Abstract:
Learning-associated functional plasticity at hippocampal synapses remains largely unexplored. Here, in a single session of reward-based trace conditioning, we examine learning-induced synaptic plasticity in the dorsal CA1 hippocampus (dCA1). Local field-potential recording combined with selective optogenetic inhibition first revealed an increase of dCA1 synaptic responses to the conditioned stimulus (CS) induced during conditioning at both Schaffer collaterals to the stratum radiatum (Rad) and temporoammonic input to the lacunosum moleculare (LMol). At these dCA1 inputs, synaptic potentiation of CS-responding excitatory synapses was further demonstrated by locally blocking NMDA receptors during conditioning and whole-cell recording sensory-evoked synaptic responses in dCA1 neurons from naive animals. An overall similar time course of the induction of synaptic potentiation was found in the Rad and LMol by multiple-site recording; this emerged later and saturated earlier than conditioned behavioral responses. Our experiments demonstrate a cued memory-associated dCA1 synaptic plasticity induced at both Schaffer collaterals and temporoammonic pathways.
