Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice.
10.1007/s12264-024-01317-9
- Author:
Xiaoyi WANG
1
;
Ziteng YUE
1
;
Luo SHI
1
;
Wei HE
1
;
Liuqi SHAO
1
;
Yuhang LIU
1
;
Jinye ZHANG
1
;
Shangyu BI
1
;
Tianjiao DENG
1
;
Fang YUAN
2
;
Sheng WANG
3
Author Information
1. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
2. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. yuanfang@hebmu.edu.cn.
3. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. wangsheng@hebmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Blood pressure;
Centromedial amygdala nucleus;
GABA;
Neural circuit;
Nucleus tractus solitarius
- MeSH:
Animals;
GABAergic Neurons/physiology*;
Male;
Central Amygdaloid Nucleus/physiopathology*;
Hypotension/physiopathology*;
Mice;
Blood Pressure/physiology*;
Mice, Inbred C57BL;
Solitary Nucleus/physiology*;
Photic Stimulation;
Neural Pathways/physiology*
- From:
Neuroscience Bulletin
2025;41(5):759-774
- CountryChina
- Language:English
-
Abstract:
The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.
