YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases.
10.1007/s12264-024-01308-w
- Author:
Lin LIN
1
;
Yinfeng YUAN
1
;
Zhihui HUANG
2
;
Yongjie WANG
3
Author Information
1. School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
2. School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China. huang0069@hznu.edu.cn.
3. School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China. wangyongjie@hznu.edu.cn.
- Publication Type:Review
- Keywords:
Hippo pathway;
Nervous system;
Nervous system diseases;
Neuroglia;
YAP
- MeSH:
Humans;
Animals;
Neuroglia/metabolism*;
Signal Transduction/physiology*;
YAP-Signaling Proteins;
Nerve Regeneration/physiology*;
Nervous System Diseases/metabolism*;
Adaptor Proteins, Signal Transducing/metabolism*
- From:
Neuroscience Bulletin
2025;41(3):501-519
- CountryChina
- Language:English
-
Abstract:
Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.
