A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid.
10.1007/s12264-024-01301-3
- Author:
Bingrui ZHU
1
;
Xiaobin HUANG
2
;
Jiahao ZHANG
1
;
Xiaoyu WANG
1
;
Sixuan TIAN
1
;
Tiantong ZHAN
1
;
Yibo LIU
1
;
Haocheng ZHANG
1
;
Sheng CHEN
3
;
Cheng YU
4
,
5
Author Information
1. Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
2. Department of Neurosurgery, The Second People's Hospital of Quzhou, Quzhou, 324000, China.
3. Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. saintchan@zju.edu.cn.
4. Department of Neurosurgery, The Second People's Hospital of Quzhou, Quzhou, 324000, China. yc661070@
5. com.
- Publication Type:Review
- Keywords:
Prediction;
Stroke;
Treatment;
Urate-lowering therapy;
Uric acid;
Uric acid therapy
- MeSH:
Humans;
Uric Acid/metabolism*;
Stroke/drug therapy*;
Animals;
Hyperuricemia/drug therapy*;
Ischemic Stroke/blood*;
Biomarkers/blood*
- From:
Neuroscience Bulletin
2025;41(3):486-500
- CountryChina
- Language:English
-
Abstract:
Stroke, a major cerebrovascular disease, has high morbidity and mortality. Effective methods to reduce the risk and improve the prognosis are lacking. Currently, uric acid (UA) is associated with the pathological mechanism, prognosis, and therapy of stroke. UA plays pro/anti-oxidative and pro-inflammatory roles in vivo. The specific role of UA in stroke, which may have both neuroprotective and damaging effects, remains unclear. There is a U-shaped association between serum uric acid (SUA) levels and ischemic stroke (IS). UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke (AIS). Urate-lowering therapy (ULT) plays a protective role in IS with hyperuricemia or gout. SUA levels are associated with the cerebrovascular injury mechanism, risk, and outcomes of hemorrhagic stroke. In this review, we summarize the current research on the role of UA in stroke, providing potential targets for its prediction and treatment.
