Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner.
10.1007/s12264-024-01292-1
- Author:
Hong CHEN
1
;
Gang YANG
2
;
De-En XU
3
;
Yu-Tong DU
1
;
Chao ZHU
1
;
Hua HU
1
;
Li LUO
4
;
Lei FENG
5
;
Wenhui HUANG
6
;
Yan-Yun SUN
7
;
Quan-Hong MA
8
Author Information
1. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
2. Lab Center, Medical College of Soochow University, Suzhou, 215021, China.
3. The Wuxi No.2 People Hospital, Wuxi, 214002, China.
4. School of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
5. Monash Suzhou Research Institute, Suzhou, 215000, China.
6. Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, University of Saarland, 66421, Homburg, Germany.
7. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. yysun@suda.edu.cn.
8. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. maquanhong@suda.edu.cn.
- Publication Type:Journal Article
- Keywords:
Autophagy;
Degradation;
Myelin proteins;
Myelination;
Oligodendrocyte precursor cells;
Oligodendrocytes;
Turnover
- MeSH:
Animals;
Autophagy/physiology*;
Oligodendroglia/metabolism*;
Myelin Sheath/physiology*;
Aging/pathology*;
Myelin Basic Protein/metabolism*;
Cell Lineage/physiology*;
Mice;
Oligodendrocyte Precursor Cells;
Mice, Inbred C57BL;
Brain/cytology*;
Cells, Cultured;
Cell Count
- From:
Neuroscience Bulletin
2025;41(3):374-390
- CountryChina
- Language:English
-
Abstract:
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.
