Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease.
10.1007/s12264-024-01299-8
- Author:
Meng-Zhu PANG
1
;
Han-Xing LI
1
;
Xue-Qin DAI
2
;
Xiao-Bo WANG
2
;
Jun-Yi LIU
3
;
Yun SHEN
1
;
Xing XU
1
;
Zhao-Min ZHONG
4
;
Han WANG
4
;
Chun-Feng LIU
5
;
Fen WANG
6
,
7
Author Information
1. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
2. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China.
3. Department of Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
4. Center for Circadian Clocks, Soochow University, Suzhou, 215123, China.
5. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. liuchunfeng@suda.edu.cn.
6. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. wangfen_1982@
7. com.
- Publication Type:Journal Article
- Keywords:
Lipid metabolism;
Melatonin;
Melatonin receptor 1;
Parkinson’s disease;
Sleep-wake disorder;
Zebrafish
- MeSH:
Animals;
Zebrafish;
Melatonin/pharmacology*;
Lipid Metabolism/drug effects*;
Disease Models, Animal;
Rotenone/pharmacology*;
Sleep Wake Disorders/metabolism*;
Parkinson Disease/metabolism*;
Motor Activity/drug effects*;
Sleep/drug effects*
- From:
Neuroscience Bulletin
2024;40(12):1901-1914
- CountryChina
- Language:English
-
Abstract:
Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease (PD). Melatonin has the potential to improve sleep-wake disorder, but its mechanism of action is still unclear. Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when melatonin receptor 1 was present. Thus, we explored the underlying mechanisms by applying a rotenone model. After the PD zebrafish model was induced by 10 nmol/L rotenone, the motor and sleep-wake behavior were assessed. In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes. In the PD model, we found abnormal lipid metabolism, which was reversed by melatonin. This may be one of the main pathways for improving PD sleep-wake disorder.
