Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.
10.1007/s12264-024-01286-z
- Author:
Yue HU
1
;
Yun WANG
1
;
Lingjing ZHANG
1
;
Mengqiang LUO
2
;
Yingwei WANG
3
Author Information
1. Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
2. Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. luomq16@fudan.edu.cn.
3. Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. wangyw@fudan.edu.cn.
- Publication Type:Review
- Keywords:
Consciousness;
Cortex;
General anesthesia;
Neural network;
Subcortical nuclei
- MeSH:
Humans;
Anesthesia, General;
Animals;
Nerve Net/physiology*;
Cerebral Cortex/drug effects*;
Neural Pathways/drug effects*;
Thalamus/drug effects*;
Consciousness/drug effects*
- From:
Neuroscience Bulletin
2024;40(12):1995-2011
- CountryChina
- Language:English
-
Abstract:
General anesthesia plays a significant role in modern medicine. However, the precise mechanism of general anesthesia remains unclear, posing a key scientific challenge in anesthesiology. Advances in neuroscience techniques have enabled targeted manipulation of specific neural circuits and the capture of brain-wide neural activity at high resolution. These advances hold promise for elucidating the intricate mechanisms of action of general anesthetics. This review aims to summarize our current understanding of the role of cortical and subcortical nuclei in modulating general anesthesia, providing new evidence of cortico-cortical and thalamocortical networks in relation to anesthesia and consciousness. These insights contribute to a comprehensive understanding of the neural network mechanisms underlying general anesthesia.
