Racial differences in treatment and prognosis of gastric signet ring cell carcinoma: analysis based on SEER and TCGA databases.
10.12122/j.issn.1673-4254.2025.08.15
- Author:
Shangping FANG
1
;
Jiameng LIU
1
;
Xingchen YUE
1
;
Huan LI
1
;
Wanning LI
1
;
Xiaoyu TANG
1
;
Pengju BAO
2
Author Information
1. School of Anesthesiology, Wuhu 241002, China.
2. School of Basic Medical Sciences, Wuhu 241002, China.
- Publication Type:Journal Article
- Keywords:
SEER analysis;
TCGA database;
columnar plots;
racial differences;
signet ring cell carcinoma
- MeSH:
Aged;
Female;
Humans;
Male;
Middle Aged;
Carcinoma, Signet Ring Cell/therapy*;
Databases, Factual;
Prognosis;
Racial Groups;
SEER Program;
Stomach Neoplasms/therapy*;
Survival Rate;
United States/epidemiology*;
White;
Asian American Native Hawaiian and Pacific Islander;
American Indian or Alaska Native;
Black or African American
- From:
Journal of Southern Medical University
2025;45(8):1706-1717
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To analyze the differences in the prognosis of gastric signet ring cell carcinoma (SRCC) among different races using the US Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.
METHODS:We analyzed the data of patients with gastric SRCC from the SEER database from 2000 to 2020, and divided the patients into cohorts of whites, blacks, Asians or Pacific Islanders, American Indians/Alaska Natives according to their race. The prognosis and treatment of the cohorts were evaluated using baseline demographic analysis, Kamplan-Meier survival curve, and nomogram analysis.
RESULTS:We analyzed the data of a total of 2058 patients, including 8.6% blacks, 72.4% whites, 16.6% Asians or Pacific Islanders, 1.0% American Indians/Alaska Natives, and 1.4% other races. The tumor grade varied among different races, and the prevalence and survival rates of patients differed significantly across races. The differences in the white cohort were the most prominent, and all the differences were statistically significant (P<0.05). Racial differences were also noted in patient management and prognosis.
CONCLUSIONS:There are racial differences in tumor grades and prognosis of gastric SRCC, and these differences provide evidence for optimizing clinical diagnosis and treatment strategies for this malignancy.
