Lip and oral cancers in East Asia from 1990 to 2035: trends of disease burden and future projections.
10.12122/j.issn.1673-4254.2025.07.23
- Author:
Yitong LIU
1
;
Ke ZHAO
2
;
Xiaodong WANG
2
Author Information
1. School of Stomatology Jinan University, Guangzhou 510632, China.
2. Hospital of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China.
- Publication Type:Journal Article
- Keywords:
East Asia;
disease burden;
lip and oral cavity cancer;
risk factors;
spatiotemporal trends
- MeSH:
Humans;
Mouth Neoplasms/epidemiology*;
Incidence;
Lip Neoplasms/epidemiology*;
Asia, Eastern/epidemiology*;
Male;
Disability-Adjusted Life Years;
Prevalence;
Female;
Forecasting;
Risk Factors;
Cost of Illness;
Middle Aged;
Global Burden of Disease;
Aged;
Bayes Theorem
- From:
Journal of Southern Medical University
2025;45(7):1554-1562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To analyze the trends of disease burden of lip and oral cancers in East Asia from 1990 to 2021 and its future projections.
METHODS:We used the Global Burden of Disease 2021 database to conduct a comprehensive analysis of disease burden data from China (including Taiwan Province of China), Japan, Republic of Korea, Democratic People's Republic of Korea and Mongolia. The data were stratified by age, gender and major risk factors, and a Bayesian age-period-cohort model was employed to predict the future trends.
RESULTS:From 1990 to 2021, the burden of lip and oral cancers in East Asian countries exhibited a steady increase. Taiwan Province of China experienced the most significant increases in incidence, prevalence, mortality, and disability-adjusted life years (DALYs), while Mongolia saw a decline in both mortality and DALYs. In 2021, Taiwan Province of China reported the highest rates of lip and oral cancer incidence (27.50 per 100 000), prevalence (137.92 per 100 000), mortality (9.59 per 100 000), and DALYs (292.07 person-years per 100 000), particularly among male and elderly populations. Tobacco use and alcohol consumption significantly exacerbated the disease burden in Taiwan Province of China and Japan. Future projections indicate that the incidence and prevalence of lip and oral cancer in China (excluding Taiwan Province of China) will continue to rise, while their mortality rates are expected to decline in most regions, except for Taiwan Province of China and Democratic People's Republic of Korea.
CONCLUSIONS:By the year 2035, the disease burden of lip and oral cancers in East Asia is expected to continue to increase, especially in Taiwan Province of China. To address this challenge, it is essential to implement effective measures to control major risk factors, promote early screening, and ensure equitable distribution of healthcare resources.
