Chronic HBV infection affects health-related quality of life in pregnant women in the second and third trimesters and postpartum period: a prospective cohort study.
10.12122/j.issn.1673-4254.2025.05.12
- Author:
Yueying DENG
1
;
Yawen GENG
1
;
Tingting PENG
2
;
Junchao QIU
3
;
Lijuan HE
4
;
Dan XIE
2
;
Ziren CHEN
2
;
Shi OUYANG
1
;
Shengguang YAN
1
Author Information
1. School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
2. Department of Infectious Diseases.
3. Department of Obstetrics, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 511495, China.
4. Department of Obstetrics and Gynecology, Kailuan General Hospital, Tangshan 063210, China.
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
pregnant women;
quality of life
- MeSH:
Humans;
Female;
Pregnancy;
Quality of Life;
Prospective Studies;
Postpartum Period;
Hepatitis B, Chronic/psychology*;
Adult;
Pregnancy Trimester, Third;
Pregnancy Trimester, Second;
Pregnancy Complications, Infectious
- From:
Journal of Southern Medical University
2025;45(5):995-1002
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To evaluate the impact of HBV infection on pre- and postpartum health-related quality of life (HRQoL) in pregnant women.
METHODS:A prospective matched cohort consisting of 70 HBV-infected and 70 healthy pregnant women was recruited from the Fifth Affiliated Hospital of Guangzhou Medical University between April 17 and September 25, 2023. HRQoL of the participants was assessed at 16-24 weeks of gestation, between 32 weeks and delivery, and 5-13 weeks postpartum. Mixed linear models were used for evaluating temporal trends of HRQoL changes, and univariate ANOVA with multiple linear regression was used to identify the predictors of HRQoL.
RESULTS:Compared with healthy pregnant women, HBV-infected pregnant women had consistently lower total HRQoL scores across all the 3 intervals, with the lowest scores observed between 32 weeks of gestation and delivery, during which these women had significantly reduced mental component scores (74.27±13.43 vs 80.21±12.9, P=0.009) and postpartum mental (76.52±16.19 vs 85.02±6.51, P<0.001) and physical component scale scores (77.17±14.71 vs 83.09±10.1, P=0.009). HBV infection was identified as an independent risk factor affecting HRQoL during late pregnancy and postpartum periods. Additional independent risk factors for postpartum HRQoL reduction included self-pay medical expenses, spouse's neutral attitude toward the current pregnancy, and preexisting comorbidities (all P<0.05).
CONCLUSIONS:HRQoL of pregnant women deteriorates progressively in late pregnancy, and HBV infection exacerbates reductions of physical function and role emotion in late pregnancy and after delivery, suggesting the importance of targeted interventions for financial burdens, partner support and comorbid conditions to improve HRQoL of pregnant women with HBV infection.
