GGN repeat length of the androgen receptor gene is associated with antral follicle count in Chinese women undergoing controlled ovarian stimulation.
10.12122/j.issn.1673-4254.2025.02.01
- Author:
Xinyan LIU
1
;
Qi FAN
2
;
Mingfen DENG
1
;
Yan XU
1
;
Jing GUO
1
;
Ping CAO
3
;
Canquan ZHOU
1
;
Yanwen XU
1
Author Information
1. Guangdong Provincial Key Laboratory of Reproductive Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China.
2. Reproductive Medicine Center, Huizhou Municipal Central Hospital, Huizhou 516001, China.
3. Research School for Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.
- Publication Type:Journal Article
- Keywords:
GGN polymorphism;
androgen receptor;
ovarian reserve;
ovarian stimulation
- MeSH:
Adult;
Female;
Humans;
Genotype;
Ovarian Follicle/cytology*;
Ovarian Reserve/genetics*;
Ovulation Induction/methods*;
Polymorphism, Genetic;
Receptors, Androgen/genetics*;
East Asian People/genetics*
- From:
Journal of Southern Medical University
2025;45(2):213-222
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To evaluate the association of GGN repeat polymorphism of androgen receptor (AR) with ovarian reserve and ovarian response in controlled ovarian stimulation (COS).
METHODS:This genetic association study was conducted among a total of 361 women aged ≤40 years with basal FSH≤12 U/L undergoing the GnRH-agonist long protocol for COS in a university-affiliated IVF center. GGN repeat in the AR gene was analyzed with Sanger sequencing. The primary endpoint was the number of antral follicle counts (AFCs), and the secondary endpoints were stimulation days, total dose of gonadotropin (Gn) used, total number of retrieved oocytes, ovarian sensitivity index, and follicular output rate.
RESULTS:The GGN repeat in exon 1 of the AR gene ranged from 13 to 24, and the median repeat length was 22. Based on the genotypes (S for GGN repeats <22, L for GGN repeats ≥22), the patients were divided into 3 groups: SS, SL, and LL. Generalized regression analysis indicated that the number of AFCs in group SS was significantly lower than those in group SL (adjusted β=1.8, 95% CI: 0.2-3.4, P=0.024) and group LL (adjusted β=1.5, 95% CI: 0.2-2.7, P=0.021). No significant difference was observed in the number of AFCs between group SL and group LL (P>0.05). Generalized regression analysis indicated no significant differences in ovarian stimulation parameters among the 3 groups, either before or after adjusting for confounding factors (P>0.05).
CONCLUSIONS:GGN repeat length on the AR gene is associated with AFC but not with ovarian response in Chinese women, indicating that AR gene polymorphisms may affect ovarian reserve.
