Association between serum BIN1 level and Killip class in patients with acute myocardial infraction.
10.12122/j.issn.1673-4254.2024.12.15
- Author:
Yanni WANG
1
;
Xia HUANG
1
;
Fuheng CHEN
2
;
Yuanyuan GAO
3
;
Xiangrong CUI
4
;
Qin YAN
5
;
Xuan JING
1
Author Information
1. Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China.
2. Clinical Laboratory, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan 030012, China.
3. Statistics for Laboratory Animal Centre, Shanxi Provincial People's Hospital, Taiyuan 030012, China.
4. Reproductive Medicine Center, Women and Children's Health Center of Shanxi Province, Taiyuan 030013, China.
5. Second Clinical College of Shanxi Medical University, Taiyuan 030002, China.
- Publication Type:Journal Article
- Keywords:
Killip classifications;
TIMI scores;
acute myocardial infraction;
bridging integrator 1;
neutrophils-to-lymphocyte ratio
- MeSH:
Humans;
Myocardial Infarction/diagnosis*;
Tumor Suppressor Proteins/blood*;
Adaptor Proteins, Signal Transducing/blood*;
Retrospective Studies;
Nuclear Proteins/blood*;
Lymphocytes/cytology*;
Neutrophils/cytology*;
Female;
Male;
Prognosis;
Middle Aged
- From:
Journal of Southern Medical University
2024;44(12):2388-2395
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the correlation of serum levels of bridging integrating factor 1 (BIN1) with acute myocardial infarction (AMI) and Killip class of the patients.
METHODS:We retrospectively collected the data from 94 patients with AMI and 30 healthy individuals for analysis of the correlations of serum BIN1 levels with Killip class, TIMI scores, and neutrophil-to-lymphocyte ratio (NLR). We also assessed the diagnostic value of BIN1 combined with NLR for AMI.
RESULTS:Serum BIN1 levels were significantly lower in AMI patients than in the healthy individuals (P=0.032). The AMI patients with Killip class I had significantly lower serum BIN1 levels than the healthy individuals (P=0.008). Serum BIN1 level was an independent predictor of AMI with a predictive value of 0.630 (95% CI: 0.513-0.748) at the optimal cutoff level of 0.341 ng/mL, a specificity of 50%, and a sensitivity of 78.5%. Serum BIN1 level was also an independent predictor for Killip class I group in the AMI patients with a predictive value of 0.672 (95% CI: 0.548-0.797) at the optimal cutoff level of 0.287 ng/mL, a specificity of 74.1%, and a sensitivity of 60%. For AMI diagnosis, the combination of NLR and serum BIN1 level had a predictive value of 0.811 (95% CI: 0.727-0.895) at the optimal cutoff level of 0.548 ng/mL, with a specificity of 92.6% and a sensitivity of 62.2%. There was a positive correlation between serum BIN1 level and TIMI score in AMI patients (r=0.186, P=0.003).
CONCLUSIONS:BIN1 is correlated with AMI and can be helpful for predicting short-term prognosis of the patients, and BIN1 combined with NLR has a high diagnostic value for AMI.
