Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.
- Author:
Qihui ZHOU
1
;
Panpan CEN
1
;
Zhi CHEN
2
,
3
;
Jie JIN
4
,
5
Author Information
- Publication Type:Review
- Keywords: Liver disease; Mitophagy; Nrf2 signaling pathway
- MeSH: Humans; NF-E2-Related Factor 2/metabolism*; Mitophagy/physiology*; Kelch-Like ECH-Associated Protein 1/metabolism*; Signal Transduction; Liver Diseases/etiology*; Animals; Oxidative Stress; Mitochondria/metabolism*; Non-alcoholic Fatty Liver Disease; Liver Neoplasms
- From: Journal of Zhejiang University. Science. B 2025;26(10):972-994
- CountryChina
- Language:English
- Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles that function in diverse metabolic processes in the body, including redox reactions, lipid metabolism, and cell death. Mitophagy, a specific form of autophagy for damaged mitochondria, plays a critical role in the pathophysiology of liver diseases. In this review, we explain in detail the roles of the Nrf2 signaling pathway and mitophagy, and the relationship between them, in various hepatic diseases (nonalcoholic fatty liver disease, viral hepatitis, alcoholic liver disease, drug-induced liver injury, autoimmune hepatitis, hepatic ischemia‒reperfusion injury, and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.
