Research progress on the intervention mechanism and clinical application of Hyssopus cuspidatus in pulmonary disease
- VernacularTitle:神香草对肺部疾病的干预作用机制与临床应用研究进展
- Author:
Rongrong ZHAO
1
;
Wei TAN
2
;
Haifang LI
3
;
Man DING
4
;
Yanmeng HU
2
;
Jinhua HE
2
Author Information
1. College of Pharmacy，Xinjiang Medical University，Urumqi 830011，China
2. Institute of Pediatrics，Xinjiang Uygur Autonomous Region Children’s Hospital，Urumqi 830054，China
3. Pharmacology and Microbiology Testing Laboratory，Xinjiang Uygur Autonomous Region Institute of Drug Control，Urumqi 830054，China
4. Drug Analysis Laboratory，Xinjiang Uygur Autonomous Region Institute of Pharmaceutical Research，Urumqi 830010，China
- Publication Type:Journal Article
- Keywords:
Hyssopus cuspidatus;
pulmonary diseases
- From:
China Pharmacy
2025;36(23):3012-3016
- CountryChina
- Language:Chinese
-
Abstract:
Hyssopus cuspidatus is an authentic medicinal herb used in Xinjiang， rich in the chemical constituents including flavonoids， phenolic acids and terpenoids. It possesses anti-inflammatory， antioxidant， and immunomodulatory effects. Modern pharmacological studies have demonstrated that H. cuspidatus exerts therapeutic effects on asthma by inhibiting airway inflammatory responses， suppressing airway remodeling， modulating the function of the hypothalamic-pituitary-adrenal axis， and relaxing bronchial smooth muscle. It also demonstrates intervention effects on chronic obstructive pulmonary disease by reducing levels of inflammatory cytokines and regulating immune balance. Additionally， H. cuspidatus can mitigate acute lung injury by inhibiting oxidative stress and intervene in lung cancer by suppressing proliferation and promoting apoptosis of lung cancer cells. In terms of clinical application， compound preparations containing H. cuspidatus， such as Hanchuan zupa granules and Luo’ou kezupa， have demonstrated favorable therapeutic effects on pulmonary diseases including asthma， cough， and pediatric bronchopneumonia. Currently， the research on precise action targets and compound matching rules of H. cuspidatus remains inadequate. Future studies should integrate modern technologies such as metabolomics to conduct in-depth exploration， thereby promoting the modernized development and clinical application of this traditional medicinal herb.
