Research progress on the pharmacological mechanisms of Acorus tatarinowii-Polygala tenuifolia herb pair in ameliorating cognitive impairment
- VernacularTitle:石菖蒲-远志药对改善认知障碍的药理机制研究进展
- Author:
Xin YANG
1
;
Yumin XU
2
;
Huayu YAN
1
;
Yuan LIU
1
;
Shiyu LIU
1
;
Hongcai XU
1
;
Yabo WU
3
Author Information
1. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China;Henan Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine，Zhengzhou 450046，China
3. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
Acorus tatarinowii;
Polygala tenuifolia;
herb pair;
cognitive impairment;
Alzheimer’s disease;
vascular cognitive
- From:
China Pharmacy
2025;36(23):3007-3011
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is a major public health challenge facing global aging societies， and currently lacks effective treatment measures. Herb pair， characterized by their rigorous compatibility and synergistic effects， demonstrate unique advantages in clinical practice. Acorus tatarinowii-Polygala tenuifolia is a classic herbal pair for treating cognitive impairment， widely utilized in various traditional Chinese medicine formulations， such as Kaixin san， Shenghui tang， and Yuanzhi san. This article summarizes the pharmacological mechanisms of A. tatarinowii， P. tenuifolia and their compatible compound prescriptions in ameliorating cognitive impairment. It is found that they can exert effects in ameliorating cognitive impairment through mechanisms such as reducing amyloid β-protein deposition and inhibiting excessive phosphorylation of Tau protein， suppressing inflammatory responses， alleviating oxidative stress， protecting neurons and regulating neurotransmitters， modulating the structure and function of the blood- brain barrier， and regulating autophagy. Subsequently， in-depth analysis can be conducted on the active ingredients of A. tatarinowii- P. tenuifolia herb pair that ameliorate cognitive impairment， along with the addition of relevant clinical trials for verification. This will provide theoretical foundations and research approaches for the treatment of cognitive impairment using traditional Chinese medicine.
