Research progress on the pharmacological mechanism of Rehmannia glutinosa in diabetic kidney disease
- VernacularTitle:地黄在糖尿病肾病中的药理作用机制研究进展
- Author:
Di NIU
1
;
Ruifang CHEN
1
;
Xinmeng HUANG
1
;
Changchang LI
1
;
Hansong ZHOU
1
;
Xinxin PANG
2
Author Information
1. Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450011，China
2. Dept. of Nephrology，Henan Province Hospital of Traditional Chinese Medicine （the Second Affiliated Hospital of Henan University of Chinese Medicine），Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
Rehmannia glutinosa;
catalpol;
verbascoside;
Rehmannia glutinosa polysaccharides
- From:
China Pharmacy
2025;36(23):2995-3000
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the most common and harmful microvascular complications of diabetes， and there is currently a lack of effective treatment methods to delay its progression. Traditional Chinese medicine has a long history of treating DKD and offers unique advantages. As a traditional Chinese medicine， Rehmannia glutinosa has shown potential in the treatment of DKD in clinical and modern pharmacological research. After integrating relevant research on the pharmacological mechanism of R. glutinosa in treating DKD， it has been found that the main active components of R. glutinosa， such as catalpol， rehmannioside D， aucubin， verbascoside， salidroside， echinacoside and R. glutinosa polysaccharides， along with its extracts and compounds （such as Liuwei dihuang pills， Shenqi dihuang decoction， and Shenqi pills）， can exert multiple effects by intervening in various signaling pathways， including advanced glycation end product （AGE）/receptor for AGE， nuclear factor kappa-B （NF- κB）， and transforming growth factor-β1 （TGF-β1）/Smads. These effects include ameliorating metabolic disorders and oxidative stress in DKD， inhibiting the processes of renal inflammation and fibrosis， regulating cell death modalities including apoptosis and ferroptosis， as well as autophagy， and reshaping the gut microbiota. Consequently， it can improve physical and chemical indices and renal tissue pathological damage， thus delaying the progression of DKD.
