Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy.
10.1016/j.apsb.2025.08.012
- Author:
Xiaoxuan GUAN
1
;
Binbin ZOU
2
;
Weiqian JIN
3
;
Yan LIU
2
;
Yongfeng LAN
2
;
Jing QIAN
4
;
Juan LUO
5
;
Yanjun LEI
5
;
Xuzhi LIANG
3
;
Shiyu ZHANG
3
;
Yuting XIAO
1
;
Yan LONG
1
;
Chen QIAN
1
;
Chaoyu HUANG
1
;
Weili TIAN
6
;
Jiahao HUANG
2
;
Yongrong LAI
2
;
Ming GAO
3
;
Lin LIAO
1
Author Information
1. Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning 530021, China.
2. Department of Hematology, Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
3. Department of Gynecology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
4. Cardiothoracic Surgery Intensive Care Unit, Cardiovascular Injury and Repair Engineering Research Center of Guangxi Department of Education, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
5. Department of Endocrinology, Department of Intensive Care Unit, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410000, China.
6. Molecular Neurogenetics, German Cancer Research Center, Heidelberg 69120, Germany.
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Albumin nanocluster;
Immunoregulation activation;
Macrophage M2 polarization;
NF-κB pathway inhibition;
NIR enhanced therapy;
Nanozyme;
ROS scavenging
- From:
Acta Pharmaceutica Sinica B
2025;15(11):5891-5907
- CountryChina
- Language:English
-
Abstract:
Acute lung injury (ALI) has been a kind of acute and severe disease that is mainly characterized by systemic uncontrolled inflammatory response to the production of huge amounts of reactive oxygen species (ROS) in the lung tissue. Given the critical role of ROS in ALI, a Fe3O4 loaded bovine serum albumin (BSA) nanocluster (BF) was developed to act as a nanomedicine for the treatment of ALI. Combining with NIR irradiation, it exhibited excellent ROS scavenging capacity. Significantly, it also displayed the excellent antioxidant and anti-inflammatory functions for lipopolysaccharides (LPS) induced macrophages (RAW264.7), and Sprague Dawley rats via lowering intracellular ROS levels, reducing inflammatory factors expression levels, inducing macrophage M2 polarization, inhibiting NF-κB signaling pathway, increasing CD4+/CD8+ T cell ratios, as well as upregulating HSP70 and CD31 expression levels to reprogram redox homeostasis, reduce systemic inflammation, activate immunoregulation, and accelerate lung tissue repair, finally achieving the synergistic enhancement of ALI immunotherapy. It finally provides an effective therapeutic strategy of BF + NIR for the management of inflammation related diseases.
