Unlocking the potential of targeted protein degradation via nanoparticle-based universal strategy.
10.1016/j.apsb.2025.09.016
- Author:
Ti-Qiang ZHOU
1
;
Weilun SUN
1
;
Zhen-Zhen WEI
2
;
Yuhua WENG
1
;
Dongxu ZHAO
1
;
Mengjie ZHANG
1
;
Yuanyu HUANG
1
Author Information
1. School of Life Science, School of Interdisciplinary Science, Aerospace Center Hospital, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical, Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China.
2. Integrated Chinese and Western Medicine Institute for Children Health and Drug Innovation, Institute of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
- Publication Type:Letter
- Keywords:
Cellular transport;
Lysosomes;
Nanomedicine;
Nanoparticle-based strategy;
Nanoparticles;
PROTAC;
Proteins of interest;
Targeted protein degradation
- From:
Acta Pharmaceutica Sinica B
2025;15(11):6082-6086
- CountryChina
- Language:English
-
Abstract:
Targeted protein degradation via nanoparticle-based universal strategy modifies nanoparticles with antibodies and ingeniously utilizes its cellular transport characteristics. This strategy achieved targeted degradation of extracellular proteins without complex design.Image 1.
