Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management.
10.1016/j.apsb.2025.08.016
- Author:
Zheng ZHAO
1
;
Zhiwei CHEN
1
;
Jacques CROMMEN
2
;
Shengfeng HUANG
3
;
Qiqin WANG
1
;
Zhengjin JIANG
1
Author Information
1. Institute of Pharmaceutical Analysis, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research of China, Jinan University, Guangzhou 510632, China.
2. Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, University of Liège, Liège B-4000, Belgium.
3. School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
- Publication Type:Review
- Keywords:
Clinically relevant antibody;
Critical illnesses;
Disease biomarkers;
Electrochemical biosensors;
Immunoassay method;
Point-of-care testing;
Precise diagnostic;
Therapeutic drug monitoring
- From:
Acta Pharmaceutica Sinica B
2025;15(11):5632-5662
- CountryChina
- Language:English
-
Abstract:
Autoimmune diseases, cancers, and viral infections pose significant global health threats, characterized by chronic pathology, unregulated cellular proliferation, and rapid transmission, respectively, requiring urgent early warning and treatment strategies. Antibodies, primarily classified into autoantibodies and therapeutic antibodies based on their clinical roles, provide essential information and show considerable value in the precise diagnosis and treatment of these serious diseases. Among the technologies utilized in bioanalysis, electrochemical biosensors, with their unique advantages of rapid response, high sensitivity, miniaturization, cost-effectiveness and user-friendly operation, have been developed as a trending technology for precise diagnostic and therapeutic drug monitoring. This review systematically summarizes the relationships and roles of clinically relevant antibodies in autoimmune diseases, cancers, and viral infections, while detailing the composition, strategies, development, and application trends of relevant electrochemical biosensors. Furthermore, it highlights the remaining challenges and opportunities for the advancement and prospects of electrochemical sensors in the context of clinically relevant antibodies.
