Protein palmitoylation: A potential therapeutic target in cardiovascular diseases.
10.1016/j.apsb.2025.07.041
- Author:
Sijia ZHAO
1
;
Yanyan YANG
2
;
Hong LI
3
;
Pin SUN
1
;
Xiangqin HE
1
;
Chao WANG
4
;
Jingjing ZHANG
5
;
Yu TIAN
1
;
Tao YU
1
;
Zhirong JIANG
1
Author Information
1. Department of Cardiac Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
2. Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao 266000, China.
3. Clinical Laboratory, Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao 266000, China.
4. Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
5. Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao 266000, China.
- Publication Type:Review
- Keywords:
Cardiac diseases;
Diagnosis;
Drugs;
Epigenetics;
Palmitoylation;
Pharmacologic;
Therapy;
Vascular diseases
- From:
Acta Pharmaceutica Sinica B
2025;15(10):5127-5144
- CountryChina
- Language:English
-
Abstract:
Palmitoylation, an essential covalent attachment of a fatty acid (usually C16 palmitate) to cysteine residues within proteins, is crucial for regulating protein functionality and enzymatic activities. This lipid modification facilitates the anchoring of proteins to cellular membranes, dictating their subcellular distribution and influencing protein transport dynamics and intracellular positioning. Additionally, it plays a role in regulating protein degradation through the ubiquitin-proteasome system. Palmitoylation is implicated in the pathogenesis and progression of cardiovascular diseases by modulating substrates and prompting additional post-translational modifications, as well as by interacting with other molecular alterations. Moreover, an intervention strategy focusing on palmitoylation processes is anticipated to offer novel therapeutic avenues for cardiovascular pathologies and address extant challenges in clinical settings. This review consolidates current research on the role and importance of palmitoylation in cardiovascular diseases by exploring its regulatory functions, the catalyzing enzymes, and the involved substrates. It highlights recent discoveries connecting palmitoylation-targeted therapies to cardiovascular health and examines potential approaches and future challenges in cardiovascular treatment.
