Trends in intestinal aging: From underlying mechanisms to therapeutic strategies.
10.1016/j.apsb.2025.05.011
- Author:
Yajun WANG
1
;
Xueni ZHANG
1
;
Mengli QING
1
;
Wen DANG
1
;
Xuemei BAI
1
;
Yingjie WANG
1
;
Di ZHOU
1
;
Lingjuan ZHU
1
;
Degang QING
2
;
Juan ZHANG
2
;
Gang CHEN
1
;
Ning LI
1
Author Information
1. School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Xinjiang Institute of Chinese Materia Medica and Ethnical Materia, Xinjiang Key Laboratory of Chinese Materia Medica and Ethnic Materia Medica, Urumqi 830002, China.
- Publication Type:Review
- Keywords:
Cross-talk;
Intestinal aging;
Intestinal epithelial renewal;
Intestinal permeability;
Intestine-derived systemic inflammation;
Mechanism;
Stem cell;
Therapeutic strategy
- From:
Acta Pharmaceutica Sinica B
2025;15(7):3372-3403
- CountryChina
- Language:English
-
Abstract:
Intestinal aging is central to systemic aging, characterized by a progressive decline in intestinal structure and function. The core mechanisms involve dysregulation of epithelial cell renewal and gut microbiota dysbiosis. In addition to previous results in model organisms like Drosophila melanogaster, recent studies have shown that in mammalian models, aging causes increased intestinal permeability and intestinal-derived systemic inflammation, thereby affecting longevity. Therefore, anti-intestinal aging can be an important strategy for reducing frailty and promoting longevity. There are three key gaps remaining in the study of intestinal aging: (1) overemphasis on aging-related diseases rather than the primary aging mechanisms; (2) lack of specific drugs or treatments to prevent or treat intestinal aging; (3) limited aging-specific dysbiosis research. In this review, the basic structures and renewal mechanisms of intestinal epithelium, and mechanisms and potential therapies for intestinal aging are discussed to advance understanding of the causes, consequences, and treatments of age-related intestinal dysfunction.
