Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: Mechanism analysis and application prospects.
10.1016/j.apsb.2025.05.021
- Author:
Yuelin HUANG
1
;
Chunting WANG
1
;
Yanhong CHEN
2
;
Dengbin WANG
2
;
Defan YAO
1
Author Information
1. Shanghai University of Sport, Shanghai 200438, China.
2. Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
- Publication Type:Review
- Keywords:
Anti-tumor immunity;
Cancer;
Gasdermin protein;
Immunogenic cell death;
Nanomedicine;
Pyroptosis;
Reactive oxygen species;
Tumor microenvironments
- From:
Acta Pharmaceutica Sinica B
2025;15(7):3487-3510
- CountryChina
- Language:English
-
Abstract:
Pyroptosis is a new type of programmed cell death that can efficiently enhance the immune response by inducing cell lysis and inflammation, thereby facilitating tumor immunotherapy. Recently, an increasing number of studies have revealed close relationships between pyroptosis and nanomedicine, which has been regarded as a new strategy for developing nanomedicine-based immunotherapy for highly effective therapy of various cancers. In this review, the development and associated signaling pathways for pyroptosis, including the correlation between pyroptosis and anti-tumor immunity, were first presented. Then, various nanomedicines that induce pyroptosis for tumor therapy, especially immunotherapy, were systematically discussed. Finally, the current challenges and constructive perspectives in this field were proposed.
