PRIME, a temperature-guided language model revolutionizes protein engineering.
10.1016/j.apsb.2025.04.010
- Author:
Yuanxi YU
1
;
Qianhui WANG
2
;
Yike ZOU
2
Author Information
1. Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.
2. School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
- Publication Type:Letter
- Keywords:
Deep learning;
Directed evolution;
Enzyme activity;
Mutant fitness prediction;
Pre-trained language model;
Protein engineering;
Protein language model;
Thermal stability
- From:
Acta Pharmaceutica Sinica B
2025;15(6):3343-3345
- CountryChina
- Language:English
