<i>Veronica anagallis-aquatica</i> L. iridoid glycosides alleviate heart failure <i>via</i> metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota.

Author: Manjiong WANG ¹ ; Xiaobo GUO ¹ ; Hanfang LIU ¹ ; Xiao LI ¹ ; Yue YAO ¹ ; Qing FU ¹ ; Yu JIN ¹ ; Shuaishuai NI ² ; Xiaokang LI ¹ ; Chaojiang XIAO ³ ; Bei JIANG ³ ; Conglong XIA ³ ; Jian LI ¹ ; Yixiang XU ¹
Author Information

1. State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
2. Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
3. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Institute of Materia Medica & College of Pharmacy, Dali University, Dali 671000, China.
Publication Type:Letter
Keywords: 2-Hydroxy-3,4-dimethoxybenzoic acid; Cardiac hypertrophy; Gut microbiota; HDAC2; Heart failure; Homoveratrumic acid; Iridoid glycosides; Metabolite
From: Acta Pharmaceutica Sinica B 2025;15(6):3338-3342
CountryChina
Language:English
Abstract: The iridoid glycosides from Veronica anagallis-aquatica L. alleviate heart failure by modulating the gut microbiota and influencing the production of two metabolites with potential antihypertrophic effects, HVA and 2OH-VA.Image 1.