"Weibing" in traditional Chinese medicine-biological basis and mathematical representation of disease-susceptible state.
10.1016/j.apsb.2025.03.009
- Author:
Wanyang SUN
1
;
Rong WANG
1
;
Shuhua OUYANG
1
;
Wanli LIANG
1
;
Junwei DUAN
2
;
Wenyong GONG
3
;
Lianting HU
4
;
Xiujuan CHEN
4
;
Yifang LI
1
;
Hiroshi KURIHARA
1
;
Xinsheng YAO
1
;
Hao GAO
1
;
Rongrong HE
1
Author Information
1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China.
2. Faculty of Data Science, City University of Macau, Macau 999078, China.
3. College of Information Science and Technology, Jinan University, Guangzhou 510632, China.
4. Medical Big Data Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510632, China.
- Publication Type:Review
- Keywords:
Disease-susceptible state;
Mathematical modeling;
Preventive medicine;
Traditional Chinese medicine;
Weibing
- From:
Acta Pharmaceutica Sinica B
2025;15(5):2363-2371
- CountryChina
- Language:English
-
Abstract:
"Weibing" is a fundamental concept in traditional Chinese medicine (TCM), representing a transitional state characterized by diminished self-regulatory abilities without overt physiological or social dysfunction. This perspective delves into the biological foundations and quantifiable markers of Weibing, aiming to establish a research framework for early disease intervention. Here, we propose the "Health Quadrant Classification" system, which divides the state of human body into health, sub-health, disease-susceptible state, and disease. We suggest the disease-susceptible stage emerges as a pivotal point for TCM interventions. To understand the intrinsic dynamics of this state, we propose laboratory and clinical studies utilizing time-series experiments and stress-induced disease susceptibility models. At the molecular level, bio-omics technologies and bioinformatics approaches are highlighted for uncovering intricate changes during disease progression. Furthermore, we discuss the application of mathematical models and artificial intelligence in developing early warning systems to anticipate and avert the transition from health to disease. This approach resonates with TCM's preventive philosophy, emphasizing proactive health maintenance and disease prevention. Ultimately, our perspective underscores the significance of integrating modern scientific methodologies with TCM principles to propel Weibing research and early intervention strategies forward.
