Modified probiotics and the related combinatorial therapeutics.

Luo ZHAO; Mengya NIU; Zilin MA; Fengyun HE; Xinxin LIU; Xunwei GONG; Zhanfei CHAI; Ziqing WANG; Qianhua FENG; Lei WANG

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Modified probiotics and the related combinatorial therapeutics.

Author: Luo ZHAO ¹ ; Mengya NIU ¹ ; Zilin MA ¹ ; Fengyun HE ¹ ; Xinxin LIU ¹ ; Xunwei GONG ¹ ; Zhanfei CHAI ¹ ; Ziqing WANG ¹ ; Qianhua FENG ¹ ; Lei WANG ¹
Author Information

1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Publication Type:Review
Keywords: Biomedical modification; Combinatorial therapeutics; Physicochemical modification; Probiotics
From: Acta Pharmaceutica Sinica B 2025;15(5):2431-2453
CountryChina
Language:English
Abstract: Probiotics have shown excellent application prospects in preventing and treating many diseases. However, their sensitivity to the harsh environment in vivo always leads to a massive loss of viability and insufficient therapeutic effect. Fortunately, modified probiotics have emerged and provide multiple possibilities for their use in various diseases. Modification not only endows probiotics with extra capacity to resist severe environments but also gives them exogenous characteristics, such as prolonged retention time and improved therapeutic effects. Modified probiotics could combine with other therapies, which has opened up new avenues to enhance the efficacy of probiotic-based therapy. In this review, we have summarized the current physicochemical and biological modification strategies of probiotics. In addition, the progress of research on probiotic-based combination therapy has also been extensively reviewed, which contributes to the enhanced delivery of probiotics or other active constituents and provides new ideas for disease treatment, bioimaging, and diagnosis.