Bacterial extracellular vesicles for gut microbiome-host communication and drug development.
10.1016/j.apsb.2025.03.008
- Author:
Dingfei QIAN
1
;
Peijun XU
1
;
Xinwei WANG
1
;
Chong DU
2
;
Xiao ZHAO
2
;
Jiaqi XU
1
Author Information
1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
2. The Comprehensive Breast Care Center, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
- Publication Type:Review
- Keywords:
BEVs inspired drugs;
Bacterial extracellular vesicles (BEVs);
Clinical diagnostic biomarker;
Engineered BEVs;
Gut microbiome-host;
Pathogenicity;
Separation and detection of BEVs;
Therapeutics
- From:
Acta Pharmaceutica Sinica B
2025;15(4):1816-1840
- CountryChina
- Language:English
-
Abstract:
As the intricate interplay between microbiota and the host garners increasing research attention, a significant parallel surge has emerged in the investigation of intestinal bacterial extracellular vesicles (BEVs). Most intestinal bacteria secrete BEVs, which harbor specific cargo molecules and exhibit diverse functions, encompassing interactions among bacteria themselves and between bacteria and the host. These interactions can either bolster host health or contribute to various pathologies. By integrating the characteristics of BEVs, we summarized the current research landscape, delving into the intricate interplay between BEVs and different diseases. Furthermore, we offer a succinct overview of the challenges faced in BEVs-based research, encompassing separation, detection, engineering for drug purposes, clinical diagnostics, safety, and future study. In essence, these summaries may serve as invaluable guides for BEVs as communication tools between the gut microbiome and host, ultimately propelling the discovery of novel studies and drug discovery.
