Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells.

Author: Xinyi TAO ¹ ; Li ZOU ¹ ; Wenxin FANG ¹ ; Ruolan ZHANG ¹ ; Jianhui LIANG ² ; Yan WANG ² ; Lei CHEN ¹
Author Information

1. School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, China.
2. Center for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Publication Type:Letter
Keywords: Cancer; Molecular glue; Oncology drug; PROTAC; TPD; Tumor organoid; scRNA-seq
From: Acta Pharmaceutica Sinica B 2025;15(4):2278-2282
CountryChina
Language:English