Overview of host-directed antiviral targets for future research and drug development.
10.1016/j.apsb.2025.03.011
- Author:
Xiaoxia GU
1
;
Mengzhu ZHENG
1
;
Ya GAO
2
;
Shuang LIN
1
;
Xiaotian ZHANG
1
;
Chunmei CHEN
1
;
Hucheng ZHU
1
;
Weiguang SUN
1
;
Yonghui ZHANG
1
Author Information
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
- Publication Type:Review
- Keywords:
Antiviral;
Drug development;
Host-directed target;
Hsps;
IRFs;
Ubiquitin–proteasome system;
Virus-host interaction;
miRNAs
- From:
Acta Pharmaceutica Sinica B
2025;15(4):1723-1751
- CountryChina
- Language:English
-
Abstract:
Viruses constitute a significant group of pathogens that have caused numerous fatalities and substantial economic losses in recent years, particularly with the emergence of coronaviruses. While the impact of SARS-CoV-2 appears to be diminishing in daily life, only a limited number of drugs have received approval or emergency use authorization for its treatment. Given the high mutation rate of viral genomes, host-directed agents (HDAs) have emerged as a preferred choice due to their broad applicability and lasting effectiveness. In contrast to direct-acting antivirals (DAAs), HDAs offer several advantages, including broad-spectrum antiviral activities, potential efficacy against future emerging viruses, and a lower likelihood of inducing drug resistance. In our review article, we have synthesized known host-directed antiviral targets that span diverse cellular pathways and mechanisms, shedding light on the intricate interplay between host cells and viruses. Additionally, we have provided a brief overview of the development of HDAs based on these targets. We aim for this comprehensive analysis to offer valuable perspectives and insights that can guide future antiviral research and drug development efforts.
