Amyloid-like fibrils derived from <i>β</i>-sheets of gp120 contribute to the neuronal pathology of HIV-associated neurocognitive disorders.

Author: Chan YANG ¹ ; Ruyu WANG ¹ ; Chen CHENG ¹ ; Jiaqi YU ² ; Kunyu LU ¹ ; Haobin LI ¹ ; Jinshen WANG ¹ ; Guodong HU ³ ; Hao YANG ¹ ; Jianfu HE ¹ ; Hao SU ¹ ; Qingping ZHAN ¹ ; Suiyi TAN ¹ ; Tong ZHANG ² ; Shuwen LIU ¹
Author Information

1. Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory of Drug Metabolism Research and Evaluation, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
2. Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
3. Department of Respiratory and Critical Care Medicine, Institute of Respiratory and Critical Care Medicine, the Tenth Affiliated Hospital of Southern Medical University, Southern Medical University, Guangdong 523059, China.
Publication Type:Letter
Keywords: Amyloid peptides; C–C chemokine receptors type 5 (CCR5); HIV-1 gp120; HIV-associated neurocognitive disorders (HAND); Neuropathology
From: Acta Pharmaceutica Sinica B 2025;15(4):2273-2277
CountryChina
Language:English