Post-translational modifications of collagen and its related diseases in metabolic pathways.
10.1016/j.apsb.2025.02.007
- Author:
Linghong GUO
1
;
Weiyi XIANG
1
;
Zhaoping PAN
1
;
He GU
1
;
Xian JIANG
1
Author Information
1. Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Review
- Keywords:
Collagen;
Collagen metabolism;
Diseases;
Epigenetic modification;
Epigenetics;
Fibrosis;
Pharmacology;
Post-translational modifications
- From:
Acta Pharmaceutica Sinica B
2025;15(4):1773-1795
- CountryChina
- Language:English
-
Abstract:
As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stability of human tissues and organs. Disorders associated with collagen structure and metabolisms impose a significant burden on society and healthcare systems. Post-translational modifications (PTMs) are essential steps in collagen metabolism, and recent studies have indicated that aberrant regulation of PTMs plays a pivotal role in the pathogenesis and progress of collagen-related disorders, including liver, kidney, heart, lung, and skin fibrosis, as well as keloid. This review provides a comprehensive summary of the regulatory mechanisms of both traditional and novel PTMs in collagen metabolism and collagen-related diseases. Furthermore, we summarize the drugs that modulate PTMs and their effects, with the aim of elucidating the pathophysiology of collagen-related diseases and provide new insights for their diagnosis, prevention, and treatment.
