Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence.
10.1016/j.apsb.2025.01.026
- Author:
Jiaqing YANG
1
;
Junhao XU
1
;
Ziheng QIU
1
;
Zhiyong MAO
1
;
Xiaojun XU
2
;
Ying JIANG
1
;
Guizhu WU
3
Author Information
1. Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
2. Department of Pharmacy, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Center for Innovative Traditional Chinese Medicine Target and New Drug Research, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.
3. Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
- Publication Type:Letter
- Keywords:
Cellular senescence;
Lycorine hydrochloride;
UBA1;
Ubiquitin-activating enzyme
- From:
Acta Pharmaceutica Sinica B
2025;15(3):1696-1699
- CountryChina
- Language:English
