NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition.
10.1016/j.apsb.2024.12.017
- Author:
Yijian GAO
1
;
Yachao ZHANG
2
;
Yujie MA
1
;
Xiliang LI
1
;
Yu WANG
1
;
Huan CHEN
3
;
Yingpeng WAN
1
;
Zhongming HUANG
1
;
Weimin LIU
4
;
Pengfei WANG
4
;
Lidai WANG
5
;
Chun-Sing LEE
3
;
Shengliang LI
1
Author Information
1. College of Pharmaceutical Sciences, the Fourth Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University, Suzhou 215123, China.
2. Key Laboratory of Biomedical Imaging Science and System, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
3. Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, Hong Kong SAR 999077, China.
4. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
5. Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.
- Publication Type:Journal Article
- Keywords:
Breast carcinoma;
Immunotherapy;
NIR-II;
Nanoparticles;
Photothermal therapy;
Semiconducting oligomer;
Theranostics;
Vaccine
- From:
Acta Pharmaceutica Sinica B
2025;15(2):1159-1170
- CountryChina
- Language:English
-
Abstract:
High-performance phototheranostics with combined photothermal therapy and photoacoustic imaging have been considered promising approaches for efficient cancer diagnosis and treatment. However, developing phototheranostic materials with efficient photothermal conversion efficiency (PCE), especially over the second near-infrared window (NIR-II, 1000-1700 nm), remains challenging. Herein, we report an ultraefficient NIR-II-activated nanomedicine with phototheranostic and vaccination capability for highly efficient in vivo tumor elimination and metastasis inhibition. The NIR-II nanomedicine of a semiconducting biradical oligomer with a motor-flexible design was demonstrated with a record-breaking PCE of 87% upon NIR-II excitation. This nanomedicine inherently features extraordinary photothermal stability, good biocompatibility, and excellent photoacoustic performance, contributing to high-contrast photoacoustic imaging in living mice and high-performance photothermal elimination of tumors. Moreover, a whole-cell vaccine based on a NIR-II nanomedicine with NIR-II-activated performance was further designed to remotely activate the antitumor immunologic memory and effectively inhibit tumor occurrence and metastasis in vivo, with good biosafety. Thus, this work paves a new avenue for designing NIR-II active semiconducting biradical materials as a promising theranostics platform and further promotes the development of NIR-II nanomedicine for personalized cancer treatment.
