Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds.
10.1016/j.apsb.2024.08.024
- Author:
Zeyu XU
1
;
Lixiang ZHANG
1
;
Qinghan TANG
1
;
Chenxi YANG
1
;
Xiaotong DING
1
;
Ziyu WANG
2
;
Rizhong HUANG
1
;
Ruihan JIANG
1
;
Joannake MAITZ
3
;
Huaikai SHI
4
;
Xin YAN
5
;
Mei DONG
1
;
Jun CHEN
1
;
Yiwei WANG
1
Author Information
1. Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. School of Life and Environmental Sciences, the University of Sydney, NSW 2006, Australia.
3. ANZAC Research Institute, Concord Hospital, University of Sydney, NSW 2138, Australia.
4. Asbestos and Dust Diseases Research Institute, Concord, NSW 2138, Australia.
5. Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210003, China.
- Publication Type:Journal Article
- Keywords:
Immune response;
Inflammation;
MatriDerm®;
Natural scaffolds;
Polycaprolactone;
Synthetic scaffolds;
Wound commensal microbiome;
Wound healing
- From:
Acta Pharmaceutica Sinica B
2025;15(1):611-626
- CountryChina
- Language:English
-
Abstract:
In current clinical practice, various dermal templates and skin substitutes are used to enhance wound healing. However, the role of wound commensal microbiome in regulating scaffold performance and the healing process remains unclear. In this study, we investigated the influence of both natural and synthetic scaffolds on the wound commensal microbiome and wound repair in three distinct models including diabetic wounds, burn injuries, and germ-free (GF) wounds. Remarkably, synthetic electrospun polycaprolactone (PCL) scaffolds were observed to positively promote microbiome diversity, leading to enhanced diabetic wound healing compared to the natural scaffolds Integra® (INT) and MatriDerm® (MAD). In contrast, both natural and synthetic scaffolds exhibited comparable effects on the diversity of the microbiome and the healing of burn injuries. In GF wounds with no detectable microorganisms, a reversed healing rate was noted showing natural scaffold (MAD) accelerated wound repair compared to the open or the synthetic scaffold (PCL) treatment. Furthermore, the response of the wound commensal microbiome to PCL scaffolds appears pivotal in promoting anti-inflammatory factors during diabetic wound healing. Our results emphasize that the wound commensal microbiome, mediated by different scaffolds plays an important role in the wound healing process.
