Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms.
10.1016/j.apsb.2024.07.003
- Author:
Zheng-An LI
1
;
Kai-Chao WEN
1
;
Ji-Heng LIU
2
;
Chuan ZHANG
1
;
Feng ZHANG
2
;
Feng-Qian LI
1
Author Information
1. School of Medicine, Shanghai University, Shanghai 200444, China.
2. Department of Urology/Pharmaceutics, Shanghai Eighth People's Hospital, Shanghai 200235, China.
- Publication Type:Review
- Keywords:
Bladder;
Bladder cancer;
Carrier design;
Delivery mechanism;
Intravesical drug delivery;
Intravesical therapy;
Penetration;
Transport barrier
- From:
Acta Pharmaceutica Sinica B
2024;14(11):4738-4755
- CountryChina
- Language:English
-
Abstract:
Intravesical drug delivery (IDD), as a noninvasive, local pathway of administration, has great clinical significance for bladder diseases, especially bladder cancer. Despite the many advantages of IDD such as enhanced focal drug exposure and avoidance of systemic adverse drug reactions, the effectiveness of drug delivery is greatly challenged by the physiological barriers of the bladder. In this review, the routes and barriers encountered in IDD are first discussed, and attention is paid to the potential internal/mucosal retention and absorption-transport mechanisms of drugs. On this basis, the avoidance, overcoming and utilization of the "three barriers" is further emphasized, and current design and fabrication strategies for intravesical drug delivery systems (IDDSs) are described mainly from the perspectives of constructing drug reservoirs, enhancing permeability and targeting, with the hope of providing systematic understanding and inspirations for the research of novel IDDSs and their treatment of bladder diseases.
