The efficacy of drug combination with immunotherapy in pediatric obstructive sleep apnea and allergic rhinitis after surgery.
10.13201/j.issn.2096-7993.2025.12.011
- Author:
Zongtong LIN
1
;
Ling SHEN
1
;
Xinzhong GAO
1
;
Qiaoyu LIAO
1
;
Zhongjie YANG
1
;
Pingfan LIU
1
Author Information
1. Department of Otolaryngology，Fuzhou First General Hospital Affiliated with Fujian Medical University/Fuzhou Children's Hospital of Fujian Province，Fuzhou，350005，China.
- Publication Type:Journal Article
- Keywords:
adenotonsillectomy;
allergic rhinitis;
clinical efficacy;
obstructive sleep apnea;
pediatric;
sublingual immunotherapy
- MeSH:
Humans;
Sleep Apnea, Obstructive/surgery*;
Rhinitis, Allergic/therapy*;
Quality of Life;
Child;
Tonsillectomy;
Treatment Outcome;
Adenoidectomy;
Sublingual Immunotherapy;
Drug Therapy, Combination;
Male;
Female
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(12):1163-1170
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of using drug combination and sublingual immunotherapy（SLIT） for pediatric obstructive sleep apnea（OSA） and allergic rhinitis（AR） after adenotonsillectomy, in order to provide a more optimized treatment plan after the surgery. Methods:A total of 95 pediatric OSA combined with AR were selected. According to the treatment plan, they were divided into the SLIT group（postoperative medication combined with SLIT） and the control group（postoperative medication treatment only）. The comparisons were made between the two groups regarding the scores of the 18-item Quality of Life Questionnaire for Obstructive Sleep Apnea（OSA-18） and the Visual Analogue Scale（VAS） before and at 1 month, 3 months, 6 months, 1 year, and 2 years after treatment; the monthly total medication scores（TMS） from 1 month to 3 months, 4 months to 6 months, 7 months to 1 year, and 1 year to 2 years after treatment, as well as the number of acute attacks of AR in the 1st year and 2nd year after treatment; and the Lund-Kennedy scores and nasal resistance grading of nasal endoscopy before and at 1 month, 3 months, 6 months, 1 year, and 2 years after treatment. The effectiveness and safety were also analyzed. Results:After one year of treatment, the OSA-18 score, VAS score, TMS and Lund-Kennedy score in the SLIT group were significantly better than those in the control group. The nasal resistance was significantly reduced（P<0.05）, and the frequency of AR attacks was significantly lower than that in the control group（P<0.05）. After 2 years of treatment, the VAS score, Lund-Kennedy score and nasal resistance classification in the SLIT group tended to stabilize, while the OSA-18 score continued to decline. Conclusion:After surgery for pediatric OSA combined with AR, the use of drugs combined with SLIT can effectively alleviate AR symptoms, further improve OSA-related symptoms and quality of life, reduce drug dependence, decrease the frequency of AR attacks, and enhance the long-term efficacy of the surgery.
