Clinical efficacy evaluation of single-dose arterial infusion chemotherapy for head and neck malignant tumors.
10.13201/j.issn.2096-7993.2025.11.017
- Author:
Jiusi LIANG
1
;
Longzhu ZHAO
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery，the Third Medical Center of PLA General Hospital，College of Otolaryngology Head and Neck Surgery，Chinese PLA General Hospital，National Clinical Research Center for Otolaryngologic Diseases，Key Lab of Hearing Science，Ministry of Education，Beijing Key Lab of Hearing Impairment for Prevention and Treatment，Beijing，100039，China.
- Publication Type:Journal Article
- Keywords:
head and neck malignant tumors;
intra-arterial chemotherapy;
neoadjuvant chemotherapy;
vascular high selectivity
- MeSH:
Humans;
Head and Neck Neoplasms/drug therapy*;
Infusions, Intra-Arterial;
Cisplatin/administration & dosage*;
Fluorouracil/administration & dosage*;
Middle Aged;
Male;
Female;
Antineoplastic Combined Chemotherapy Protocols/administration & dosage*;
Aged;
Adult;
Treatment Outcome;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(11):1094-1098
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of single-dose arterial infusion chemotherapy（using cisplatin+5-fluorouracil（5-FU）） as a preoperative treatment for locally advanced head and neck malignant tumors, and to reassess tumor burden and lesion extent to guide the development of individualized treatment strategies. Methods:A total of 23 patients with locally advanced head and neck malignant tumors underwent preoperative assessments to determine the extent of the tumor and TNM staging. Treatment options were discussed with the patients and their families. Patients with significant tumor burden and a strong preference for preserving organ function received single-dose arterial infusion chemotherapy, followed by the formulation of an individualized treatment plan. A catheter was inserted through the femoral artery and selectively cannulated into the tumor-supplying artery via the external carotid artery, allowing direct infusion of chemotherapy drugs into the tumor core. Four weeks post-procedure, tumor burden was re-evaluated, and postoperative TNM staging was confirmed, leading to the development of an individualized treatment plan. Results:Among the 23 patients with head and neck malignant tumors, 4 achieved a complete respones（tumor reduction>75%）, 17 achieved a partial response（tumor reduction>50%）. One patient with recurrent oropharyngeal cancer received chemotherapy combined with immunotherapy after the T stage was reduced through treatment. In 113patients with hypopharyngeal cancer and 7 with oropharyngeal cancer, the surgical approach was optimized following treatment. Tow patient with hypopharyngeal cancer showed a stable disease response（tumor reduction>25% or no new lesions）, and after further assessment, a total laryngectomy was deemed appropriate. Conclusion:Among 23 patients with arterial infusion chemotherapy, the T stage of the 21 patients with head and neck malignant tumors decreased, and the local tumor burden was significantly reduced. Additionally, changes were observed in the size, shape, and boundaries of the cervical lymph nodes relative to surrounding tissues.
