Progress of scRNA-seq technology in nasopharyngeal carcinoma research.
10.13201/j.issn.2096-7993.2025.09.017
- Author:
Bin ZHENG
1
;
Guanqiao JIN
1
Author Information
1. Radiology Department of Guangxi Medical University Affiliated Cancer Hospital，Nanning，530021，China.
- Publication Type:English Abstract
- Keywords:
nasopharyngeal carcinoma;
single-cell RNA sequencing;
tumor heterogeneity;
tumor microenvironment
- MeSH:
Humans;
Nasopharyngeal Neoplasms/genetics*;
Tumor Microenvironment;
Nasopharyngeal Carcinoma;
Single-Cell Analysis;
Sequence Analysis, RNA;
Precision Medicine;
Drug Resistance, Neoplasm;
Epstein-Barr Virus Infections;
Herpesvirus 4, Human;
Single-Cell Gene Expression Analysis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(9):889-893
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma（NPC） is a distinct type of head and neck cancer closely associated with Epstein-Barr virus（EBV） infection and exhibits significant geographic variations in its incidence. Despite recent advancements in radiotherapy techniques and precision medicine for NPC, the overall survival rate remains unsatisfactory due to tumor metastasis, recurrence, and drug resistance. Single-cell RNA sequencing（scRNA-seq） is an emerging technology that allows for the analysis of gene expression at single-cell resolution, providing a clearer understanding of tumor cell subpopulations, the evolutionary trajectory of tumor cells, and the functional roles and interactions of cells within the tumor microenvironment. This provides new ideas for the development of precision medicine in NPC. Here, we review the applications of scRNA-seq in exploring the mechanisms of NPC pathogenesis, tumor heterogeneity, the tumor microenvironment, drug resistance, and therapeutic response.
