Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss.
- Author:
Xinyu SHI
;
Xianbao CAO
;
Renjie CHAI
;
Suijun CHEN
;
Juan FENG
;
Ningyu FENG
;
Xia GAO
;
Lulu GUO
;
Yuhe LIU
;
Ling LU
;
Lingyun MEI
;
Xiaoyun QIAN
;
Dongdong REN
;
Haibo SHI
;
Duoduo TAO
;
Qin WANG
;
Zhaoyan WANG
;
Shuo WANG
;
Wei WANG
;
Ming XIA
;
Hao XIONG
;
Baicheng XU
;
Kai XU
;
Lei XU
;
Hua YANG
;
Jun YANG
;
Pingli YANG
;
Wei YUAN
;
Dingjun ZHA
;
Chunming ZHANG
;
Hongzheng ZHANG
;
Juan ZHANG
;
Tianhong ZHANG
;
Wenqi ZUO
;
Wenyan LI
;
Yongyi YUAN
;
Jie ZHANG
;
Yu ZHAO
;
Fang ZHENG
;
Yu SUN
- Publication Type:Consensus Development Conference
- Keywords: cochlear implantation; genetic diagnosis; hereditary hearing loss
- MeSH: Humans; Cochlear Implantation; Prognosis; Hearing Loss/surgery*; Consensus; Connexin 26; Mutation; Sulfate Transporters; Connexins/genetics*
- From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2025;39(9):798-808
- CountryChina
- Language:Chinese
- Abstract: Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI. Drawing upon domestic and international research and clinical experience, it proposes an evidence-based medicine three-tiered prognostic classification system（Favorable, Marginal, Poor）. The consensus focuses on common hereditary non-syndromic hearing loss（such as that caused by mutations in genes like GJB2, SLC26A4, OTOF, LOXHD1） and syndromic hereditary hearing loss（such as Jervell & Lange-Nielsen syndrome and Waardenburg syndrome）, which are closely associated with congenital hearing loss, analyzing the impact of their pathological mechanisms on CI outcomes. The consensus provides recommendations based on multiple round of expert discussion and voting. It emphasizes that genetic diagnosis can optimize patient selection, predict prognosis, guide post-operative rehabilitation, offer stratified management strategies for patients with different genotypes, and advance the application of precision medicine in the field of CI.